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HMX Fundamentals

Get an in-depth look at how the body fights disease – and how new therapies can help.

Microbial life forms are an ever-present, extremely dangerous threat to our survival, against which the immune system must constantly defend.

In HMX Fundamentals Immunology, you’ll learn about the processes that enable our immune systems to respond to evolving threats, and learn about new, immunology-based disease treatments.

Course Topics


  • Course introduction
  • Meet the faculty
  • Basic terms and concepts

Innate Immunity and Inflammation

  • Sentinel cells and circulating leukocytes
  • Inflammatory events and signaling
  • The formation of pus

Microbial Recognition and Responses in Innate Immunity

  • Pattern recognition receptors
  • Innate immune signaling
  • The antiviral state
  • The complement system

Antibodies – Structure and Function

  • B lymphocytes
  • Antibody structure and function
  • How antibodies can cause disease

Lymphocyte Development and Diversity

  • Lymphocyte development
  • Clonal selection and expansion
  • Differences between B and T lymphocytes
  • The generation of lymphocyte receptor diversity

T Cell Activation by Antigens

  • The role of dendritic cells
  • The lymphatic system and delivery of antigen to lymph nodes
  • Adaptive immune activation in secondary lymphoid tissues
  • Costimulation and inhibitory signaling
  • Antigen presentation

T Cell-Dependent B Cell Responses

  • T Cell activation of B cells
  • The germinal center reaction
  • Isotype switching and affinity maturation

Helper T Cells

  • Helper T cell functions
  • Helper T cell subsets
  • The role of helper T cells in disease

Cytotoxic T Cells

  • Cytotoxic T cell functions
  • Selection and expansion of cytotoxic T cells
  • Contraction and memory
  • Therapies that target cytotoxic T cell functions

Failures of the Immune System

  • Immunodeficiencies
  • Mechanisms of tolerance and loss of self-tolerance
  • Autoimmune diseases
  • Allergic diseases

Immunology-Based Therapy of Diseases

  • Transplantation and transfusion
  • Vectored immunoprophylaxis and chimeric antigen receptor T cells
  • Neoantigen discovery and checkpoint blockade

Course Instructors

Andrew Lichtman, Harvard Medical School

Andrew Lichtman, MD, PhD

Professor of Pathology, Harvard Medical School
Senior Pathologist, Brigham and Women’s Hospital

Why do you think it’s important for aspiring health care professionals to learn immunology?

Over the past several decades, there has been an enormous increase in the scientific evidence for a central role of the immune system in a wide range of common human diseases, including those that cause the most morbidity and mortality worldwide. Many of these disorders had traditionally not been viewed through the immunology lens, such as cancer and cardiovascular disease, but that is all changing now.  Therefore, a basic understanding of the components, functions, and mechanisms of the immune system is really an essential foundation for anyone planning to train for a career in healthcare.

What do you want students to take away from this course?

On completion of the course, students should understand the fundamental ways the immune system protects us, and appreciate how deficiencies, excesses, or mistargeting of immune responses contribute to disease. Furthermore, students should be aware of the many ways the science of immunology has already been successfully translated into clinical medicine. The basic knowledge gained from this course should facilitate students’ continued course-based and self-learning of immunology.

Shiv Pillai, Harvard Medical School

Shiv Pillai, MD, PhD

Professor of Medicine and Health Sciences and Technology, Harvard Medical School
Immunologist and Geneticist, Center for Cancer Research, Massachusetts General Hospital
Director, MMSc in Immunology Program, Harvard Medical School
Associate Program Head, Graduate Program in Immunology, Harvard Medical School

Why do you think it’s important for aspiring health care professionals to learn immunology?

The immune system protects us from infections and cancer in a very exquisitely precise way. Most human diseases result from some loss of this precision. Sometimes the immune system is overwhelmed by an infection or a tumor. On other occasions the immune system aberrantly or over-exuberantly responds to innocuous environmental molecules or microbes – or to self-structures – and this results in a loss of immune regulation that results in disease. Understanding immunology has allowed the prevention of infections by the use of vaccines, has helped the medical world develop the ability to transfuse blood making modern surgery possible, has allowed transplantation to become a reality, and has led to rational treatments for allergies and autoimmune diseases, and what are likely the first real cures for cancer. Many of the therapies of the future will likely be derived from an even better understanding of immunology and how the loss of immune regulation leads to specific diseases. No other field of basic science is so intimately connected to the pathogenesis of disease or to treatment.

What do you want students to take away from this course?

Students should understand the underlying concepts of how the immune system works and how knowledge of immunology has already impacted the understanding and treatment of a range of human disorders.

What Learners Say

Allie Hyans

Allie Hyans

Celgene Corporation / Harvard Business School

“I almost didn’t know how applicable it would be until after I became familiar with the concepts discussed in the course, and now they come up all the time…for my own personal understanding, it’s made a world of difference.”

Siyan Xu

Siyan Xu


“The topics are so well organized, and I think the lectures cover those fundamental ideas very well.”

Ana Castillo Orozco

Ana Castillo Orozco

National Institute of Genomic Medicine (Mexico)

“I have taken a lot of courses online, but this was a very different approach…The disease linkage piece was so important because you could enhance your knowledge based on what you saw. It was so amazing how doctors chose patients that covered the whole concepts that you learned in class, and how they chose a particular patient that fit in the clinical scenario.”

Khalil Ragland

Khalil Ragland

Central Connecticut State University

“I was impressed by the way that each topic was broken down into chunks that you could really understand…you could go through it at the pace that was best for you.”

Read more learner profiles