Learn Genetics Online
Understand the building blocks of life – and the future of medicine.
The way we diagnose and treat diseases is changing, with new technologies enabled by a deeper understanding of the human genome and its relationship to health and disease.
In HMX Fundamentals Genetics, you’ll get an overview of fundamental concepts behind the evolving fields of human genetics, genomics, and precision medicine.
This online certificate course is led by Harvard Medical School faculty and features:
- detailed animations and illustrations of medical concepts
- clinical application videos including real doctor-patient interactions
- ongoing, rigorous assessments to ensure content mastery
Learn more about the course:
Course Information
Upcoming course periods
January 14 – March 28, 2025 | Apply now through January 6
Partial tuition waiver application deadline: Tuesday, November 26 at 12 noon US ET (HMX Fundamentals only)
April 15 – June 27, 2025 | Application opens December 11
June 3 – August 15, 2025 | Application opens March 26
Course length
Each course is 10 weeks long. New lessons are released weekly, and material remains available until the course closes. Expect to spend 3-6 hours per course per week.
Course cost
US$995 for an individual course
What Learners Say
David Hall
Biostatistician
“I do a little bit of learning through osmosis in my job, because we do analysis on genetic data, so I learn kind of as I go. But this has helped push me forward greatly – this was awesome.”
Ana de Pina
University of New England College of Medicine
“The HMX Genetics course just made a huge difference for me…It was explained really well, the review questions were challenging enough to really make me think about it. I learned new things that I never knew before.”
Jacques Balayla, MD
“I found that the way [HMX] organized the course was just the right approach; it makes sense cohesively without going into too much unnecessary detail or too much memorization. Though I was not completely new to the topic, it felt like I was learning again because of the way that it was provided.”
Course Topics
Overview
- Course introduction
- Meet the faculty
- Introduction to the human genome
The Central Dogma and Genetic Variation
- The relationship between genotype and phenotype
- Structure of a human gene and the effects of genetic variation
Mendelian Inheritance of Disease
- Meiotic segregation
- Modes of inheritance
- Pedigree analysis
- Penetrance and expressivity
Identifying Mendelian Disease Genes
- Haplotypes and linkage studies
- Determining causation of a variant
- Targeted genetic testing
Chromosomal Aberrations
- DNA segregation machinery
- Whole chromosome and structural aneuploidy
- Diagnostic techniques for chromosomal disorders
The Genetics of Cancer
- Germline and somatic mutations
- Tumor suppressors and oncogenes
- Two hit hypothesis
- Precision cancer treatments
Common Complex Traits
- Architecture of a complex trait
- Genome-wide association studies
- Heritability and missing heritability
- Understanding risk in common complex traits
Human Population Genetics
- Emergence and history of human traits
- Evolutionary forces and population dynamics
- Ancestry testing and population-specific risk
Beyond the Genome Sequence
- Mitochondrial inheritance
- Unstable repeats
- Epigenetic inheritance and imprinting
- Gene dosage and X-inactivation
Genetics and Precision Medicine
- Whole genome sequencing
- Pharmacogenomics
- Genome editing
Course Instructors
Christine DeGennaro, PhD
Lecturer in Genetics, Harvard Medical School
Robert C. Green, MD, MPH
Professor of Medicine, Harvard Medical School
Associate Physician, Brigham and Women’s Hospital
Geneticist, Brigham and Women’s Hospital
Director, Genomes2People Research Program at Brigham and Women’s Hospital
Carrie Blout, MS, CGC, LGC
Senior Genetic Counselor and Project Manager, Brigham & Women’s Hospital